News & Media
3. Clinical Studies
3.4 Stem Cell Educator therapy in type 1 diabetes
Reversal of Type 1 Diabetes via Islet beta Cell Regeneration Following Immune Modulation by Cord Blood-Derived Multipotent Stem Cells
Journal: BMC Medicine. 10(1): 3, January 2012
Yong Zhao*, Zhaoshun Jiang, Tingbao Zhao, et al.
Modulation of autoimmune T-Cell memory by Stem Cell Educator therapy: phase 1/2 clinical trial
Journal: EBioMedicine. 2: 2024-2036, December 2015
Authors: Elias Delgado, Marcos Perez-Basterrechea, et al., Yong Zhao*.
Platelets-derived mitochondria display embryonic stem cell markers and improve pancreatic islet β-cell function in humans
Journal: STEM CELLS Translational Medicine. 6: 1684-1697, July 2017
Yong Zhao*, Zhaoshun Jiang, Elias Delgado, et al.
3.3 Stem Cell Educator Therapy in type 2 diabetes
Targeting insulin resistance via the immune modulation of cord blood-derived multipotent stem cells by the Stem Cell Educator Therapy
Journal: Diabetes. 61: S1, A-75, 2012
Authors: Yong Zhao*, Zhaoshun Jiang, Mingliang Ye, et al.
Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial
Journal: BMC Medicine. 11(1):160, July 2013
Authors: Yong Zhao*, Zhaoshun Jiang, Mingliang Ye, et al.
Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy
Journal: BMC Medicine. 13: 87, April 2015
Authors: Yanjia Li, Baoyong Yan, et al., Yong Zhao
3.1 Invited Review articles
Stem Cell Educator therapy in type 1 diabetes: from the bench to clinical trials.
Journal: Autoimmunity Reviews. 21: 103058, 2022 Authors: Yong Zhao*, Colette M. Knight*, Zhaoshun Jiang*, Elias Delgado*, Anne Marie Van Hoven, Steven Ghanny, Zhiguang Zhou, Huimin Zhou, Haibo Yu, Wei Hu, Heng Li, Xia Li, Marcos Perez-Basterrechea, Laura Zhao, Yeqian Zhao, Joseph Giangola, Rona Weinberg, Theodore Mazzone
Clinical Translational Potentials of Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes.
Journal: Frontiers in Endocrinology. Jan. 12, 2022
Authors: Wei Hu, … and Yong Zhao*.
Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications.
Journal: Int J Mol Sci 21(14):5163, 2020
Authors: Wei Hu, … and Yong Zhao*
New hope for type 1 diabetes mellitus: Stem Cell Educator therapy
Journal: Chinese Journal of Diabetes. 22 (3): 194 - 199, February 2014
Authors: Yong Zhao*
Stem Cell Educator Therapy and the treatment of Type 1 Diabetes.
Journal: Chinese Journal of Diabetes Mellitus. 6 (2): 69 -72, February 2014
Authors: Yong Zhao* and Zhiguang Zhou.
Stem Cell Educator Therapy and Induction of Immune Balance
Journal: Current Diabetes Reports. 12: online 2012
Authors: Yong Zhao*
New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells
Journal: Autoimmunity Reviews. 11: 137-142, 2011
Authors: Yong Zhao*, Zhao shun Jiang, Chengshan Guo
Human cord blood stem cells and the journey to a cure for type 1 diabetes
Journal: Autoimmunity Reviews. 10:103-107, 2010
Authors: Yong Zhao*, Theodore Mazzone
2. Pre-clinical Studies in Humans
2.6 A novel function of Mitochondria in cellular reprogramming
Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans
Journal: International Journal of Molecular Sciences. 21(17): 6295. August 31, 2020.
Haibo Yu, Wei Hu, Xiang Song, Yong Zhao*
Generation of Multipotent Stem Cells from Adult Human Peripheral Blood Following the Treatment with Platelet-Derived Mitochondria
Journal: Cells. 9, 1350, May 2020
Haibo Yu, Wei Hu, Xiang Song and Yong Zhao *
Generation of Hematopoietic-Like Stem Cells from Adult Human Peripheral Blood Following Treatment with Platelet-Derived Mitochondria
Journal: International Journal of Molecular Sciences. 21, 4249. June 15, 2020.
Haibo Yu, Wei Hu, Xiang Song, Yong Zhao*
2.5 Molecular mechanism underlying the immune modulation of CB-SCs
Suppression of B-Cell Activation by Human Cord Blood-Derived Stem Cells (CB-SCs) through the Galectin-9-Dependent Mechanism
Journal: International Journal of Molecular Scinences (IJMS), 2024, 25, 1830
Authors: Wei Hu, Xiang Song, Haibo Yu, Sophia Fan, Andrew Shi, Jingyu Sun, Hongjun Wang, Laura Zhao and Yong Zhao*
Differentiation of Monocytes into Phenotypically Distinct Macrophages After Treatment with Human Cord Blood Stem Cell (CB-SC)-Derived Exosomes
Journal: Journal of Visualized Experiments (JoVE). 10.3791/61562, November 2020
Authors: Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao*
Released Exosomes Contribute to the Immune Modulation of Cord Blood-Derived Stem Cells (CB-SC)
Journal: Frontiers in Immunology. 11: 165, 2020
Authors: Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao*
2.4 Identification of peripheral blood-derived insulin-producing cells (PB-IPC)
A unique human blood-derived cell population displays high potential for producing insulin
Journal: Biochemical and Biophysical Research Communications. 360: 205-211, 2007
Authors: Yong Zhao*, Z Huang, P Lazzarini, et al.
2.3 Differentiation of CB-SCs into dopamine neurons
Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons
Journal: Biochemical and Biophysical Research Communications. 419(1):110-6, 2012
Authors: Xiaohong Li, Heng Li, et al., Yong Zhao*
2.2 First demonstrate that CB-SCs display immune modulation
Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell
Journal: Immunology Letters. 108:78-87, 2007
Authors: Yong Zhao*, Zhihua Huang, Meirigeng Qi, et al.
2.1 Identification of human cord blood-derived multipotent stem cells (CB-SCs)
Identification of pluripotent stem cells from umbilical cord blood with embryonic and hematopoietic characteristics
Journal: Experimental Cell Research. 312: 2454-2464, 2006
Authors: Yong Zhao*, Honglan Wang, Theodore Mazzone.
1. Pre-clinical Studies in Mice
1.2 Establishment of humanized immune-caused type 1 diabetic mouse model
Selective Destruction of Mouse Islet Beta Cells by Human T Lymphocytes in a Newly-Established Humanized Type 1 Diabetic Model
Journal: Biochemical and Biophysical Research Communications. 399: 629-636, 2010
Yong Zhao*, Chengshan Guo, David Hwang, et al.
1.1 Demonstrate the reversal of type 1 diabetes by the immune modulation of CB-SCs in mice
Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic
Journal: Plos ONE. 4 (1): e4226, 2009
Authors: Yong Zhao*, Brian Lin, Robert Darflinger, et al.
The new type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes
Journal: Translational Research (Previous name: The Journal of Laboratory and Clinical Medicine). 155: 211-16, 2010
Authors: Yong Zhao*, Brian Lin, Michael Dingeldein, et al.
COVID-19 (SARS-COV-2)
Further comments on the role of ACE-2 positive macrophages in human lung.
Journal: Cytometry Part A: July 12, 2021
Authors: Wei Hu, … and Yong Zhao*
Little to no expression of angiotensin‐converting enzyme‐2 (ACE2) on most human peripheral blood immune cells but highly expressed on tissue macrophages
Journal: Cytometry Part A: 2020
Authors: Xiang Song, Wei Hu, Haibo Yu, Laura Zhao, Yeqian Zhao, Xin Zhao, Hai‐Hui Xue, Yong Zhao*