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3. Clinical Studies

3.4 Stem Cell Educator therapy in type 1 diabetes

Reversal of Type 1 Diabetes via Islet beta Cell Regeneration Following Immune Modulation by Cord Blood-Derived Multipotent Stem Cells

Journal: BMC Medicine. 10(1): 3, January 2012

Yong Zhao*, Zhaoshun Jiang, Tingbao Zhao, et al.

Modulation of autoimmune T-Cell memory by Stem Cell Educator therapy: phase 1/2 clinical trial

Journal: EBioMedicine. 2: 2024-2036, December 2015

Authors: Elias Delgado, Marcos Perez-Basterrechea, et al., Yong Zhao*.

Platelets-derived mitochondria display embryonic stem cell markers and improve pancreatic islet β-cell function in humans

Journal: STEM CELLS Translational Medicine. 6: 1684-1697, July 2017

Yong Zhao*, Zhaoshun Jiang, Elias Delgado, et al.

3.3 Stem Cell Educator Therapy in type 2 diabetes

Targeting insulin resistance via the immune modulation of cord blood-derived multipotent stem cells by the Stem Cell Educator Therapy

Journal: Diabetes. 61: S1, A-75, 2012

Authors: Yong Zhao*, Zhaoshun Jiang, Mingliang Ye, et al.

Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial

Journal: BMC Medicine. 11(1):160, July 2013

Authors: Yong Zhao*, Zhaoshun Jiang, Mingliang Ye, et al.

Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy

Journal: BMC Medicine. 13: 87, April 2015

Authors: Yanjia Li, Baoyong Yan, et al., Yong Zhao

3.1 Invited Review articles

Stem Cell Educator therapy in type 1 diabetes: from the bench to clinical trials.

Journal: Autoimmunity Reviews. 21: 103058, 2022

Authors: Yong Zhao*, Colette M. Knight*, Zhaoshun Jiang*, Elias Delgado*, Anne Marie Van Hoven, Steven Ghanny, Zhiguang Zhou, Huimin Zhou, Haibo Yu, Wei Hu, Heng Li, Xia Li, Marcos Perez-Basterrechea, Laura Zhao, Yeqian Zhao, Joseph Giangola, Rona Weinberg, Theodore Mazzone

Clinical Translational Potentials of Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes.

Journal: Frontiers in Endocrinology. Jan. 12, 2022

Authors: Wei Hu, … and Yong Zhao*.

Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications.

Journal: Int J Mol Sci 21(14):5163, 2020

Authors: Wei Hu, … and Yong Zhao*

New hope for type 1 diabetes mellitus: Stem Cell Educator therapy

Journal: Chinese Journal of Diabetes. 22 (3): 194 - 199, February 2014

Authors: Yong Zhao*

Stem Cell Educator Therapy and the treatment of Type 1 Diabetes.

Journal: Chinese Journal of Diabetes Mellitus. 6 (2): 69 -72, February 2014

Authors: Yong Zhao* and Zhiguang Zhou.

Stem Cell Educator Therapy and Induction of Immune Balance

Journal: Current Diabetes Reports. 12: online 2012

Authors: Yong Zhao*

New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells

Journal: Autoimmunity Reviews. 11: 137-142, 2011

Authors: Yong Zhao*, Zhao shun Jiang, Chengshan Guo

Human cord blood stem cells and the journey to a cure for type 1 diabetes

Journal: Autoimmunity Reviews. 10:103-107, 2010

Authors: Yong Zhao*, Theodore Mazzone

2. Pre-clinical Studies in Humans

2.6 A novel function of Mitochondria in cellular reprogramming

Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans

Journal: International Journal of Molecular Sciences. 21(17): 6295. August 31, 2020.

Haibo Yu, Wei Hu, Xiang Song, Yong Zhao*

Generation of Multipotent Stem Cells from Adult Human Peripheral Blood Following the Treatment with Platelet-Derived Mitochondria

Journal: Cells. 9, 1350, May 2020

Haibo Yu, Wei Hu, Xiang Song and Yong Zhao *

Generation of Hematopoietic-Like Stem Cells from Adult Human Peripheral Blood Following Treatment with Platelet-Derived Mitochondria

Journal: International Journal of Molecular Sciences. 21, 4249. June 15, 2020.

Haibo Yu, Wei Hu, Xiang Song, Yong Zhao*

2.5 Molecular mechanism underlying the immune modulation of CB-SCs

Suppression of B-Cell Activation by Human Cord Blood-Derived Stem Cells (CB-SCs) through the Galectin-9-Dependent Mechanism

Journal: International Journal of Molecular Scinences (IJMS), 2024, 25, 1830

Authors: Wei Hu, Xiang Song, Haibo Yu, Sophia Fan, Andrew Shi, Jingyu Sun, Hongjun Wang, Laura Zhao and Yong Zhao*

Differentiation of Monocytes into Phenotypically Distinct Macrophages After Treatment with Human Cord Blood Stem Cell (CB-SC)-Derived Exosomes

Journal: Journal of Visualized Experiments (JoVE). 10.3791/61562, November 2020

Authors: Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao*

Released Exosomes Contribute to the Immune Modulation of Cord Blood-Derived Stem Cells (CB-SC)

Journal: Frontiers in Immunology. 11: 165, 2020

Authors: Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao*

2.4 Identification of peripheral blood-derived insulin-producing cells (PB-IPC)

A unique human blood-derived cell population displays high potential for producing insulin

Journal: Biochemical and Biophysical Research Communications. 360: 205-211, 2007

Authors: Yong Zhao*, Z Huang, P Lazzarini, et al.

2.3 Differentiation of CB-SCs into dopamine neurons

Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons

Journal: Biochemical and Biophysical Research Communications. 419(1):110-6, 2012

Authors: Xiaohong Li, Heng Li, et al., Yong Zhao*

2.2 First demonstrate that CB-SCs display immune modulation

Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell

Journal: Immunology Letters. 108:78-87, 2007

Authors: Yong Zhao*, Zhihua Huang, Meirigeng Qi, et al.

2.1 Identification of human cord blood-derived multipotent stem cells (CB-SCs)

Identification of pluripotent stem cells from umbilical cord blood with embryonic and hematopoietic characteristics

Journal: Experimental Cell Research. 312: 2454-2464, 2006

Authors: Yong Zhao*, Honglan Wang, Theodore Mazzone.

1. Pre-clinical Studies in Mice

1.2 Establishment of humanized immune-caused type 1 diabetic mouse model

Selective Destruction of Mouse Islet Beta Cells by Human T Lymphocytes in a Newly-Established Humanized Type 1 Diabetic Model

Journal: Biochemical and Biophysical Research Communications. 399: 629-636, 2010

Yong Zhao*, Chengshan Guo, David Hwang, et al.

1.1 Demonstrate the reversal of type 1 diabetes by the immune modulation of CB-SCs in mice

Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic

Journal: Plos ONE. 4 (1): e4226, 2009

Authors: Yong Zhao*, Brian Lin, Robert Darflinger, et al.

The new type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes

Journal: Translational Research (Previous name: The Journal of Laboratory and Clinical Medicine). 155: 211-16, 2010

Authors: Yong Zhao*, Brian Lin, Michael Dingeldein, et al.

COVID-19 (SARS-COV-2)

Further comments on the role of ACE-2 positive macrophages in human lung.

Journal: Cytometry Part A: July 12, 2021

Authors: Wei Hu, … and Yong Zhao*

Little to no expression of angiotensin‐converting enzyme‐2 (ACE2) on most human peripheral blood immune cells but highly expressed on tissue macrophages

Journal: Cytometry Part A: 2020

Authors: Xiang Song, Wei Hu, Haibo Yu, Laura Zhao, Yeqian Zhao, Xin Zhao, Hai‐Hui Xue, Yong Zhao*